Overview of Different Modes and Applications of Liquid Phase-Based Microextraction Techniques

Liquid phase-based microextraction techniques (LPµETs) have attracted great attention from the scientific community since their invention and implementation mainly due to high efficiency, low solvent sample amount, enhanced selectivity precision, good reproducibility for a wide range of analytes. This review explores different possibilities applications LPμETs including dispersive liquid–liquid (DLLME) single-drop (SDME), highlighting its two main approaches, direct immersion-SDME headspace-SDME, hollow-fiber liquid-phase (HF-LPME) in two- three-phase device modes using donor–acceptor interactions, electro membrane extraction (EME). Currently, these are used very areas interest, environment food beverages, pharmaceutical, clinical, forensic analysis. Several important potential each technique will be reported, advantages drawbacks. Moreover, use alternative efficient “green” solvents nanostructured supramolecular (SUPRASs, deep eutectic (DES), ionic liquids (ILs)) discussed.